Description

1. Introduction to Trazodone 100mg

Trazodone 100mg is a prescription medication primarily used to treat major depressive disorder. It belongs to the class of serotonin antagonist and reuptake inhibitors (SARIs), which work by restoring the balance of serotonin in the brain. Beyond its primary use, Trazodone 100mg is also prescribed off-label for conditions like anxiety and insomnia due to its sedative properties.​Verywell Mind+1Drugs.com+1Drugs.com

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2. Understanding Trazodone 100mg

Trazodone functions by inhibiting the reuptake of serotonin and antagonizing certain serotonin receptors, leading to increased serotonin levels in the brain. This mechanism helps alleviate symptoms of depression and anxiety. Additionally, its antihistaminic and alpha-adrenergic blocking effects contribute to its sedative and hypnotic properties.​WebMD+10Verywell Mind+10Drugs.com+10

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3. Medical Uses of Trazodone 100mg

3.1. Treatment of Depression

Trazodone 100mg is FDA-approved for the treatment of major depressive disorder. It helps improve mood, appetite, and energy levels while reducing anxiety and insomnia associated with depression.​Drugs.com

3.2. Management of Anxiety Disorders

Off-label, Trazodone 100mg is used to manage generalized anxiety disorder and panic disorder. Its anxiolytic effects are beneficial in reducing symptoms of anxiety.​Drugs.com+6Verywell Mind+6PubMed+6

3.3. Insomnia Relief

Due to its sedative properties, Trazodone 100mg is commonly prescribed off-label to treat insomnia, especially in patients with depression. It helps in improving sleep onset and maintenance.​Verywell Health

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4. Dosage and Administration Guidelines

Trazodone 100mg should be taken exactly as prescribed by a healthcare provider. It’s typically administered orally, with or after food to reduce gastrointestinal side effects.​

4.1. Dosage for Depression

The initial dose for treating depression is usually 150mg per day, divided into multiple doses. Depending on the patient’s response and tolerance, the dose may be increased gradually, not exceeding 400mg per day in outpatient settings.​

4.2. Dosage for Insomnia

For insomnia, lower doses ranging from 25mg to 100mg at bedtime are commonly prescribed. The sedative effect helps in initiating and maintaining sleep.​Cleveland Clinic+8Verywell Health+8WebMD+8

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5. Potential Side Effects

While Trazodone 100mg is generally well-tolerated, it may cause side effects in some individuals.​

5.1. Common Side Effects

• Drowsiness

• Dizziness

• Dry mouth

• Nausea

• Headache

• Blurred vision​Cleveland Clinic+11Wikipedia+11MedlinePlus+11

5.2. Serious Side Effects

• Priapism (prolonged and painful erection)

• Serotonin syndrome (symptoms include agitation, hallucinations, fever, and rapid heart rate)

• Orthostatic hypotension (sudden drop in blood pressure upon standing)

• Cardiac arrhythmias

• Seizures​Cleveland Clinic+1MedlinePlus+1Drugs.com+4Sprout Health Group+4Redorbit+4

If any serious side effects occur, immediate medical attention is required.​

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6. Precautions and Contraindications

Before starting 100mg, inform your healthcare provider about any existing medical conditions or medications.​

6.1. Precautions

• Use caution in patients with a history of heart disease, especially those with arrhythmias.

• Monitor for signs of suicidal thoughts, particularly in young adults.

• Use with caution in patients with liver or kidney impairment.​

6.2. Contraindications

• Hypersensitivity to Trazodone or any of its components.

• Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOIs.​

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7. Drug Interactions

100mg may interact with other medications, leading to increased side effects or reduced efficacy.​

7.1. Medications to Avoid

• MAOIs

• Other serotonergic drugs (e.g., SSRIs, SNRIs)

• CNS depressants (e.g., alcohol, benzodiazepines)

• Antihypertensive agents

• Anticoagulants and antiplatelet drugs​nhs.uk+6Drugs.com+6Beal Wellness+6

Always consult with a healthcare provider before combining Trazodone with other medications.​

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8. Overdose and Emergency Measures

An overdose of 100mg can be life-threatening. Symptoms may include extreme drowsiness, vomiting, seizures, and irregular heartbeat. In case of overdose, seek immediate medical attention or contact emergency services.